The traditional boundaries between academia and industry are increasingly blurred, with universities playing a pivotal role in driving innovation and economic growth through the commercialization of scientific discoveries. While much research has focused on the structural and policy mechanisms facilitating this transfer, less attention has been paid to the individual experiences of scientists embarking on entrepreneurial ventures. This article adopts a human-centric lens to explore the nuanced narratives of innovation, the evolution of identity, and the exercise of leadership among researchers engaged in the valorization of scientific knowledge. Drawing upon existing literature, we synthesize insights into the challenges and opportunities faced by academics as they transition from the 'ivory tower' to the commercial arena, highlighting the critical role of personal agency, evolving mindsets, and effective leadership in fostering successful knowledge transfer. Understanding these personal journeys is crucial for developing more effective support systems and fostering a culture that encourages scientific entrepreneurship, ultimately broadening the scope of knowledge impact beyond traditional economic metrics to encompass social and cultural dimensions.