Lipid Metabolism and Its Profound Influence on Biological Aging and Age-Related Pathologies
DOI:
https://doi.org/10.64917/fmcs-006Keywords:
Lipid metabolism, biological aging, age-related diseases, cellular senescenceAbstract
Lipid metabolism plays a central role in maintaining cellular homeostasis and energy balance, and its dysregulation has been increasingly implicated in the biology of aging and the development of age-related diseases. Lipids not only serve as structural components of membranes and energy sources but also act as signaling molecules that influence a wide array of physiological processes, including inflammation, oxidative stress response, and mitochondrial function. Recent research highlights how alterations in lipid profiles and lipid-processing enzymes contribute to cellular senescence, neurodegeneration, cardiovascular diseases, and metabolic syndromes commonly observed in aging populations. Understanding the mechanistic links between lipid metabolism and aging offers promising avenues for therapeutic intervention, including dietary modulation, pharmacological targeting of lipid metabolic pathways, and the use of lipidomics for early detection of age-related pathologies. This review synthesizes current insights into lipid metabolic pathways and their profound influence on the aging process and associated diseases, aiming to illuminate potential strategies for promoting healthy aging and longevity.
References
Johnson AA, Stolzing A. The role of lipid metabolism in aging, lifespan regulation, and age‐related disease. Aging Cell. 2019;18(6):e13048.
Chung KW. Advances in understanding of the role of lipid metabolism in aging. Cells. 2021;10(4):880.
Zeng Q, Gong Y, Zhu N, Shi Y, Zhang C, Qin L. Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases. Ageing Res Rev. 2024:102294.
Li X, Wang J, Wang L, Gao Y, Feng G, Li G, et al. Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Signal Transduct Target Ther. 2022;7(1):162.
Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nat Rev Endocrinol. 2022;18(4):243-258.
Saher G. Cholesterol metabolism in aging and age-related disorders. Annu Rev Neurosci. 2023;46(1):59-78.
Song R, Hu M, Qin X, Qiu L, Wang P, Zhang X, et al. The roles of lipid metabolism in the pathogenesis of chronic diseases in the elderly. Nutrients. 2023;15(15):3433.
Fransen M, Nordgren M, Wang B, Apanasets O, Van Veldhoven PP. Aging, age-related diseases and peroxisomes. Subcell Biochem. 2013:45-65.
Jové M, Portero-Otín M, Naudí A, Ferrer I, Pamplona R. Metabolomics of human brain aging and age-related neurodegenerative diseases. J Neuropathol Exp Neurol. 2014;73(7):640-657.
Mutlu AS, Duffy J, Wang MC. Lipid metabolism and lipid signals in aging and longevity. Dev Cell. 2021;56(10):1394-1407.
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Copyright (c) 2025 Dr. Elise M. Hartmann, Prof. Daniel T. Nguyen, Dr. Sofia K. Alvarez
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