This multicenter study investigates the clinicopathological features and treatment strategies for metaplastic breast carcinoma (MBC) in a Vietnamese patient cohort. MBC is a rare and aggressive subtype of breast cancer, often associated with unique histological characteristics and a poorer prognosis compared to more common breast cancer types. This research aims to provide comprehensive data on MBC in Vietnam, a region where specific epidemiological and clinical insights into this malignancy are limited. By analyzing patient demographics, tumor characteristics, treatment modalities, and outcomes from multiple institutions, this study elucidates the distinct profile of MBC in this population, contributing to a better understanding of its management in a non-Western context. The findings highlight the challenges in diagnosis and treatment and offer valuable insights for optimizing therapeutic approaches for Vietnamese patients with MBC.