The increasing complexity, scale, and release frequency of contemporary software systems have exposed limitations in conventional testing practices, particularly in exhaustive test execution, regression validation, and early defect identification. This research proposes an intelligent framework that integrates artificial intelligence (AI)-based test automation with software defect prediction to establish a proactive quality-engineering process. The proposed framework combines requirement and code analysis, automated test generation, execution prioritization, defect-risk estimation, feedback-driven model refinement, and quality reporting within a unified architecture. The methodological foundation is a conceptual synthesis of AI-driven test automation principles, with particular emphasis on automation, intelligent prioritization, and predictive quality assurance as discussed by Ramamurthy (2023). The supplied reference corpus also demonstrates how intelligent sensing, pattern recognition, resource optimization, and data-driven classification can conceptually inform automated quality-monitoring architectures, although most of these studies originate outside software testing. The proposed model therefore treats cross-domain evidence as methodological inspiration rather than direct empirical validation. The analysis indicates that combining predictive defect-risk scores with automated test selection can potentially reduce redundant testing, concentrate computational resources on high-risk software components, and improve feedback speed. However, model reliability depends on historical defect data, feature quality, distributional stability, explainability, and integration with existing development pipelines. The framework contributes a structured basis for AI-assisted software quality engineering while identifying empirical validation, benchmark datasets, and explainable prediction as priorities for future research.